Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis
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چکیده
منابع مشابه
Renal Proximal Tubule Cells
Previous data suggested an active Clconductance in the renal proximal convoluted tubule, although single channel conductance and regulation were not found. We have investigated the presence and regulation of the C1channel in proximal convoluted tubules by patch clamp analysis. The current-voltage relationship of whole cells with 130 mM NaCI in the pipette was nonlinear. The addition of 1-34 PTH...
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Phosphatidylinositol (PI) is a precursor for an important class of phospholipids, the phosphatidylinositol polyphosphates. Because renal myo-inositol levels may vary under both physiological (e.g., antidiuretic) and pathophysiological (e.g., diabetic) conditions, the formation of PI from CDP-diacylglycerol (CDP-DG) and myo-inositol via phosphatidylinositol synthase and the regulation of this en...
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Plasma membrane Ca 2 1 -ATPase (PMCA) and the Na 1 /Ca 2 1 exchanger participate in regulating cell function by maintaining proper intracellular Ca 2 1 concentrations ([Ca 2 1 ] i ). In renal epithelial cells these proteins have been additionally implicated in cellular calcium absorption. The purpose of the present studies was to determine the Ca 2 1 extrusion mechanisms in cells derived from t...
متن کاملActivation of MAPKs by Light Chains 1 Role of MAPK Pathways in Light Chain-Induced Cytokine Production in Human Proximal Tubule Cells
We previously demonstrated that light chain (LC) endocytosis by human proximal tubule cells (PTCs) leads to production of cytokines through activation of NF-κB. Here, we examined the role of MAPK pathways in these responses using four species of myeloma LCs (κ 1 , κ 2 , κ 3 and λ 1) previously shown to induce cytokine production by PTCs.. Among these, κ 1-LC that yielded the strongest cytokine ...
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The renal proximal tubule metabolizes circulating low-molecular-weight proteins such as Ig free light chains. In the setting of plasma cell dyscrasias, the burden of filtered protein can be very high. Endocytosis of certain nephrotoxic light chains induces H(2)O(2) production and monocyte chemoattractant protein-1 (MCP-1) release, leading to recruitment of inflammatory cells and interstitial fi...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.137191